ABOUT LONG COVID

An Emerging Unmet Medical Need

Approximately 30% of the 373 Million Covid-19Infected Patients Experiencing Post-COVID symptoms

 

Long Covid, involves a range of symptoms that can last for months after first being infected with SARS-CoV-2 or can even first appear weeks after the acute phase of infection has resolved. Long Covid can happen to anyone infected with SARS-CoV-2, even if the illness was mild or entirely asymptomatic.

Persistent symptoms

  • Fatigue 55%

  • Difficulty breathing 42%

  • Memory loss 34%

  • Sleep disorder 32%

  • Attention disorder 27%

  • Significant hair loss 20%

  • Cough 17% 

  • Loss of smell 13%

120 patients (mean =  111 days)

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Source: Garrigues et al. Infect. 2020;  Carifi, et. al. JAMA. 2020; J Gold, Pathogens, 2021; F Bai, Clinical Microbial Infections, 2021

The mechanisms by which COVID-19 causes lingering symptoms in survivors are not fully understood but are hypothesized to result from: 

  • Immune-system overdrive triggered by the COVID-19 virus, including increased production of autoantibodies

  • Lingering infection 

  • Co-infection/activation of previous viral infections that were dormant

Most adults are infected with normally harmless dormant viruses, contracted years earlier

COVID-19 acutely depletes our T cells, which may allow for reactivation of herpes viruses

Antiviral therapy may hold promise for treating Long Covid

  • Valacyclovir, famciclovir and acyclovir inhibit replication of these common herpes viruses

  • Valacyclovir has been shown to reduce the frequency of EBV-infected B cells

Sources: Groff et al, JAMA, Oct 2021; J Gold, Pathogens, 2021; Cox et al, Research, Penn State University, Jan 22

IMC-2 Phase 2 Exploratory Long Covid Study

Exploratory Endpoints Include: Fatigue, pain, sleep, anxiety, depression, cognitive function and global improvement  

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